[vc_row][vc_column width=”1/1″][vc_custom_heading text=”Lipinski’s rule ” font_container=”tag:h2|text_align:left” google_fonts=”font_family:Raleway%3A100%2C200%2C300%2Cregular%2C500%2C600%2C700%2C800%2C900|font_style:400%20regular%3A400%3Anormal”][vc_column_text]Lipinski’s Rule, so called “Rule of Five”, is published by Christopher A. Lipinski et al. in Pfizer Central Research (Groton, NJ,USA). They selected a subset of 2245 compounds from WDI (World Drug Index) database and defined drug-like character through this subset. The results are the followings: [ Lipinski,C.A. et al. Adv. Drug Deliv. Rev. 1997, 23, 3. ]
- No. hydrogen bond donors ≤ 5 ( The sum of OHs and NHs )
- No. hydrogen bond acceptor ≤ 10 ( The sum of Os and Ns )
- Molecular weight ≤ 500
- CLogP ≤ 5 ( MlogP ≤ 4.5 )
About 90 % of the above subset is included in defined rage with better solubility and permeability.[/vc_column_text][ultimate_spacer height=”20″][/vc_column][/vc_row]
