[vc_row][vc_column width=”1/1″][vc_custom_heading text=”Leadlike rule ” font_container=”tag:h2|text_align:left” google_fonts=”font_family:Raleway%3A100%2C200%2C300%2Cregular%2C500%2C600%2C700%2C800%2C900|font_style:400%20regular%3A400%3Anormal”][vc_column_text]Identification and optimization of lead compounds as chemical staring points are very important in combinatorial chemistry. Lead-like rule is published by Simon J. Teague et al. and defined to consider designing libraries with druglike physicochemical properties. They have divided the common sources of lead compounds for drug discovery into three types like the following figure. [ Teague,S.J.et al., Angew. Chem. Int. Ed. 1999, 38, 3743. ]


 Figure. Group of Leads of Drug

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